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Updated: Jun 21, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
09:49

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells

Published on: August 13, 2010

発達的および種別のグロービンスイッチングは,BCL11AAによって引き起こされます

Vijay G Sankaran1, Jian Xu, Tobias Ragoczy

  • 1Division of Hematology/Oncology, Children's Hospital Boston and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|August 7, 2009
PubMed
まとめ

BCL11Aのようなトランス作用因子は,進化の過程で種特有の遺伝子発現の変化を誘導する. BCL11A発現の差異は,ヒト胎児のヘモグロビン遺伝子がマウスの胚性遺伝子として機能する理由を説明する.

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