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Updated: Jun 21, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

グルコースの欠乏は,腫瘍細胞におけるKRAS経路変異の発生に寄与する

Jihye Yun1, Carlo Rago, Ian Cheong

  • 1Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

Science (New York, N.Y.)
|August 8, 2009
PubMed
まとめ

低グルコース環境は,KRASおよびBRAF遺伝子の変異を誘導することによって,がんの成長を促す可能性があります. これは,グルコーストランスポーター-1 (GLUT1) の発現が増加し,グルコース分解と栄養ストレス下での細胞生存を高めることで起こります.

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Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

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