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Updated: Jun 21, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

受容体チロシンキナーゼシグナル伝達の選択性は,二次的なSH2ドメイン結合部位によって制御されます

Jae Hyun Bae1, Erin Denise Lew, Satoru Yuzawa

  • 1Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Cell
|August 12, 2009
PubMed
まとめ

SH2ドメインの相互作用は,受容体チロシンキナーゼシグナル伝達において重要な役割を果たします. 新しい研究は,二次結合部位がフォスフォリファースCガマの選択性を調節し,細胞信号伝達経路のより複雑な視点を提供することを明らかにしています.

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