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Updated: Jul 21, 2026
11:10
Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
島細胞抗体の定量化とインスリン依存型糖尿病の予測
E Bonifacio1, P J Bingley, M Shattock
1Department of Immunology, University College, Middlesex School of Medicine, London, UK.
Lancet (London, England)
|January 20, 1990
まとめ
アイレット細胞抗体 (ICA) は,親戚の将来のインスリン依存性糖尿病 (IDDM) の発症を強く予測します. 高濃度のICAは,数年以内にIDDMを発症するリスクを大幅に高めます.
科学分野:
- 免疫学 免疫学とは
- エンドクリノロジー エンドクリノロジー
- 糖尿病に関する研究
背景:
- インスリン依存型糖尿病患者 (IDDM) の一級親族は,遺伝的傾向が強くなっています.
- アイレット細胞抗体 (ICA) は,臓のβ細胞に対する自己免疫活動のマーカーである.
- IDDMのリスクが高い個人を早期に特定することは,適切な介入に不可欠です.
研究 の 目的:
- 将来のIDDM開発のためのICAの感度と予測価値を決定する.
- ICAレベルとIDDM発症までの時間との相関を評価する.
- ICA検出の値とその予後的意義を確立する.
主な方法:
- IDDM患者の第1度の親戚719人の将来的な追跡調査は,最大10.5年間.
- ジュベニル・糖尿病財団 (JDF) の単位を用いたICAの定量化.間接免疫光による.
- ICA検出率の分析とIDDM発生率と診断までの時間との相関.
主要な成果:
- ICAは,ベースラインの3.3%の親戚とフォローアップの1.9%で検出されました.
- IDDMは,検出可能なICAを持つ親戚の35%で,検出できないICAの0.3%で発症した.
- より高いピークICAレベルは,IDDMの早期発症と相関する;IDDMの100%予測値は,10年以内に80 JDF単位>で.
結論:
- ICAは,リスクの高い個体におけるIDDM発達の非常に敏感で予測可能なマーカーである.
- ICAのレベルは,IDDMの進行のリスクと速度と正比例しています.
- ICA検査は,リスクの階層化と,感染した患者の家族でIDDMの発症を予測するのに価値があります.
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