関連する実験動画
Updated: Aug 4, 2026

13:08
Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
自己反応性ガンマデルタT細胞は,胸腺で排出される
A L Dent1, L A Matis, F Hooshmand
1Department of Biology, University of California, San Diego, La Jolla 92093.
Nature
|February 22, 1990
まとめ
トランスジェニックのガンマデルタT細胞は,TIa決定因子が欠けているマウスで正常に機能する. しかし,TIa決定因子を発現するマウスでは,これらのT細胞はリンパ性臓器に存在しないため,TIaがT細胞発現において重要な役割を果たしていることが示されています.
科学分野:
- 免疫学 免疫学とは
- T細胞の生物学について
- 分子遺伝学 分子遺伝学
背景:
- ガンマデルタT細胞は,ユニークな機能を持つTリンパ球の独特の系統です.
- T細胞受容体 (TCR) の特異性は,T細胞の発達と機能に極めて重要です.
- メジャー・ヒストコンパティビリティ・コンプレックス (MHC) クラスIの分子は,T細胞に抗原を提示する.
研究 の 目的:
- ガンマデルタT細胞の発達と機能におけるTIaロカスでコードされたMHCクラスI分子の役割を調査する.
- 変異性ガンマデルタTCR発現がマウスのT細胞集団に与える影響を決定する.
主な方法:
- マウスの細菌系に,TIaでコードされた決定因子に特異的なガンマデルタT細胞受容体の遺伝子を挿入する.
- トランスジェニックマウスのチムスおよび周辺リンパ性臓器のT細胞集団の分析.
- T細胞受容体発現レベルを評価するためのフローサイトメトリ.
主要な成果:
- 変異性ガンマデルタT細胞は,TIa決定因子が欠けているマウスのT細胞集団の機能的成分でした.
- TIa決定因子を発現するマウスでは,外周リンパ性臓器から変異性ガンマデルタT細胞が欠けていた.
- TIa決定因子を発現するマウスのチモサイトは,トランスジェニックのガンマデルタT細胞受容体のレベルが低下したことを示した.
結論:
- TIaでコードされた決定因子は,ガンマデルタT細胞の選択および/または発達において重要な役割を果たします.
- TIa決定因子の存在は,特定のTCRを発現するガンマデルタT細胞の除去または発達障害につながる.
- この研究は,T細胞レパートリー多様性を形成するMHC-TCR相互作用の重要性を強調しています.
関連する概念動画
Cell-mediated Immune Responses
Overview
Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

