胃潰瘍の病気が発症する.
Peter Malfertheiner1, Francis K L Chan, Kenneth E L McColl
1Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany. peter.malfertheiner@med.ovgu.de
Lancet (London, England)
|August 18, 2009
まとめ
胃潰瘍疾患の発生率は,酸性抑制剤とヘリコバクター・パイロリ治療の進歩により減少しています. しかし,非ステロイド性抗炎症薬 (NSAIDs) とアスピリンは依然として潰瘍を引き起こすため,継続的な管理戦略を必要とします.
科学分野:
- 胃腸内科 胃腸内科
- エピデミオロジー エピデミオロジー
- 薬理学 薬理学とは
背景:
- 胃潰瘍病は,歴史上,著しい罹病率と死亡率を引き起こしてきました.
- 近年,胃潰瘍病の発生率が著しく減少していることが示されています.
- 重要な要因には,強力な酸性抑制剤とヘリコバクター・ピロリ菌の発見が含まれます.
研究 の 目的:
- 過去25年間の胃潰瘍疾患の理解と管理における革命を振り返る.
- 非ステロイド性抗炎症薬 (NSAIDs) と低用量アスピリンの潰瘍病への影響を調査する.
- 薬剤誘発性潰瘍およびH. pylori陰性,NSAID陰性潰瘍に対する戦略について議論する.
主な方法:
- 胃潰瘍疾患における疫学的傾向のレビュー.
- ヘリコバクター・パイロリ発見が病気の理解と治療に与える影響の分析.
- 現在の潰瘍の病原性におけるNSAIDとアスピリンの役割の検討.
- 薬物誘発性潰瘍に対する治療と予防戦略の議論.
主要な成果:
- 胃潰瘍の病率の大幅な減少は,酸性抑制剤とH. pyloriの根絶に起因する.
- 非ステロイド性抗炎症薬 (NSAID) と低用量アスピリンは,現在,胃潰瘍の主要な原因となっています.
- H. pylori 陰性,NSAID 陰性潰瘍は,希少だが増大する臨床的課題を代表しています.
結論:
- 医学における進歩は,胃潰瘍疾患の管理に変革をもたらしました.
- NSAIDとアスピリンの使用は,潰瘍疾患を駆動し続けているため,標的型の予防と治療が必要です.
- 複雑な潰瘍の症例,H. pylori陰性,NSAID陰性潰瘍などの管理のためにさらなる研究が必要です.
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