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関連する概念動画

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

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Updated: Jun 20, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

痛風は痛風である.

Pascal Richette1, Thomas Bardin

  • 1Université Paris 7, UFR Médicale, Assistance Publique-Hôpitaux de Paris, Hôpital Lariboisière, Fédération de Rhumatologie, Paris, France. pascal.richette@lrb

Lancet (London, England)
|August 21, 2009
PubMed
まとめ
この要約は機械生成です。

尿酸結晶の蓄積による一般的な炎症性関節炎である痛風は,成人の1〜2%に影響します. 血清尿酸を低下させると結晶が溶け,痛風を治し,ライフスタイルの変化と併合性疾患の管理に伴います.

関連する実験動画

Last Updated: Jun 20, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

科学分野:

  • レウマトロジーの病理学
  • メタボリック疾患
  • クリスタルアーソポサシー (Crystal Arthropathies) とは,結晶アーソポサシー (Crystal Arthropathies) を意味する.

背景:

  • 痛風は,慢性高尿血症による単一ナトリウムウラート結晶の堆積によって引き起こされる一般的な炎症性関節炎です.
  • 先進国の成人の1~2%に罹患する痛風は,男性で最も一般的な炎症性関節炎であり,罹患率が上昇しています.
  • 主要性痛風は,腎臓の尿酸トランスポーターに影響を与える食事と遺伝的要因に関連しています.

研究 の 目的:

  • 痛風の疫学,原因,併発症,およびガウトの管理をレビューする.
  • 痛風管理の現在のおよび潜在的な治療目標を強調する.
  • 患者の教育と併発性疾患の治療の重要性を強調する.

主な方法:

  • 痛風の罹患率とリスク要因に関する疫学データの文献レビュー.
  • 急性痛風発作に対する現在の薬理学的治療法の分析.
  • インタレウキン-1β.をはじめとする新興治療標的の検討

主要な成果:

  • 痛風の罹患率は増加しており,ライフスタイルや遺伝的要因に関連しています.
  • 非ステロイド性抗炎症薬とコルキシンは標準的な急性治療法であり,経口コルチコステロイドは代替薬です.
  • 血清尿酸を飽和点以下に低下させると,結晶が溶け,痛風が治ります.

結論:

  • 痛風の管理には,高尿血症,急性発作,および関連する併発症に対処する必要があります.
  • 治療戦略には,ライフスタイルの変更,薬剤療法,およびインタールイキン-1β.beta.のような炎症媒介体を潜在的に標的にすることが含まれます.
  • 血清尿酸の持続的な低下を達成することは,痛風を解決し,結晶の形成を防ぐための鍵です.