関連する実験動画

Updated: Mar 23, 2026

Author Spotlight: Developing Acetyl-Click Assay for HAT1 Inhibitor Screening
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Author Spotlight: Developing Acetyl-Click Assay for HAT1 Inhibitor Screening

Published on: January 26, 2024

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HATとHDACの全ゲノムマッピングは,活性遺伝子と非活性遺伝子の異なる機能を明らかにしています

Zhibin Wang1, Chongzhi Zang, Kairong Cui

  • 1Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|August 25, 2009
PubMed
まとめ

ヒストンアセチルトランスフェラーゼ (HAT) とデセチラーゼ (HDAC) は活性遺伝子を結合し,HDACはクロマチンをリセットする. プライムされた不活性遺伝子は,ダイナミックなHAT/HDAC結合を示すが,サイレント遺伝子はHDACを欠いている.

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