仮説:乳がんは子宮から発生するのか?

D Trichopoulos¹

¹Department of Epidemiology, School of Public Health, Harvard University, Boston, Massachusetts 02115.

Lancet (London, England)

|April 21, 1990

まとめ

ホルモンのような特定の危険因子に対する産前曝露は,後の人生で癌のリスクを増やす可能性があります. この研究は,妊娠中のエストロゲン濃度の上昇が,娘の将来の乳がんの可能性を高めることを示唆しています.

科学分野:

生殖内分泌学生殖内分泌学
癌の流行病学がん流行病学
発達性毒理学について

背景:

大人のがんのリスク要因は胎児の発達に影響を与える可能性があります.
陽性放射線やダイエチルスティルベストロールなどの子宮内曝露は,発がん物質として知られています.
妊娠中のホルモンの影響は,発達に極めて重要です.

研究の目的:

産前ホルモン曝露と子孫で癌を発症するリスクとの関連を調査する.
妊娠中に母親のエストロゲン濃度の上昇は,娘の乳がんリスクの増加と相関しているという仮説を評価する.

主な方法:

産前曝露とがんリスクに関する既存の経験的データのレビューと合成.
妊娠ホルモンと子がん発生率の関連性を調べた疫学研究の分析.
子宮内発がん物質への曝露に関するヒトおよび動物のデータの比較分析.

主要な成果:

経験的データは,先天性被曝と後の癌のリスクとを結びつける仮説を裏付けている.
妊娠中の母親のエストロゲン濃度が高いことと,娘の乳がん発症の確率の増加との間には,相関関係があることが示唆されています.
特定の物質 (例えば,ディエチルスティルベストロール) に対する子宮内暴露は,がんのリスクの増加と関連しています.

結論:

リスク因子に対する産前曝露は,がんの発症に長期的な影響を及ぼす可能性があります.
妊娠中のエストロゲン濃度の上昇は,女性の子孫の乳がんの重要な危険因子である可能性があります.
このメカニズムを解明し,これらの発見を確認するためにさらなる研究が必要である.

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