関連する実験動画

Updated: Jun 20, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
06:06

In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

E3リガゼTRAF6は,Aktのユビキチン化と活性化を調節する

Wei-Lei Yang1, Jing Wang, Chia-Hsin Chan

  • 1Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Science (New York, N.Y.)
|August 29, 2009
PubMed
まとめ

タンパク質キナーゼAktのユビキチネーションは,その膜の局所化と活性化に不可欠です. このプロセスは,TRAF6によって媒介され,成長因子のシグナル伝達に不可欠であり,がんにおける腫瘍原性 Aktの活性化に寄与する.

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