慢性閉塞性肺疾患の悪化を治療する新薬

Trevor T Hansel¹, Peter J Barnes

¹National Heart and Lung Institute, Imperial College, London, UK. t.hansel@imperial.ac.uk

Lancet (London, England)

|September 1, 2009

まとめ

慢性阻害性肺疾患 (COPD) は,感染症と喫煙によって引き起こされる先天性免疫疾患です. COPDを理解する

科学分野:

免疫学免疫学とは
肺内科肺内科肺内科
感染症感染症とは

背景:

喫煙は慢性閉塞性肺疾患 (COPD) の主要な危険因子です.
ウイルス感染症と細菌感染症は,COPDの悪化の主な原因です.
反応性酸素種 (ROS),病原体関連分子パターン (PAMP),および損傷関連分子パターン (DAMP) は,トール型受容体 (TLR) を含むパターン認識受容体 (PRR) を活性化します.

研究の目的:

COPDは先天的な免疫の原型疾患であるという仮説を検証する.
COPDにおける異常な免疫反応を特徴付けるために.
COPDの予防と治療のための分子標的を特定する.

主な方法:

既存の文献のレビューと,COPDにおける先天性免疫経路の理解.
COPDの特徴の分析,障壁機能,急性相反応,免疫細胞の活性化など.
コルチコステロイド耐性や異常な修復プロセスなどの関連疾患の検査.

主要な成果:

COPDは,損傷に対する異常な先天的な免疫反応によって特徴付けられます.
主な特徴は,呼吸器系バリア機能の変化,急性相反応,マクロファージ,中性子,線維細胞の過度の活性化などです.
この病気には炎症,修復,線維症,タンパク質分解,コルチコステロイド耐性,欠陥再生が伴う.

結論:

COPDは本質的に先天性免疫疾患である.
これらの免疫メカニズムを理解することは,新しい治療戦略を開発するための基礎を提供します.
COPDの悪化を予防し,治療するために有効な薬物を発見するための臨床試験が進行中です.

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