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Updated: Jun 20, 2026

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ErbB2は,自己抑制された無脊椎動物の表皮成長因子受容体に似ています

Diego Alvarado1, Daryl E Klein, Mark A Lemmon

  • 1Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6059, USA.

Nature
|September 1, 2009
PubMed
まとめ

孤児受容体チロシンキナーゼErbB2 (HER2) は,ドロソフィラメラノガスターEGFR (dEGFR) に似たリガンドによって調節されることがあります. この発見は,ErbB2が自己抑制を欠いているという考えに異議を唱え,がんに対する新たな治療標的を提供している.

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