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Endocarditis IV: Nursing Management
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発光性上皮性幹細胞は,前立腺がんの起源細胞である
Xi Wang1, Marianna Kruithof-de Julio, Kyriakos D Economides
1Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Nature
|September 11, 2009
まとめ
研究者らは,前立腺の再生に不可欠であり,前立腺がんの潜在的な起源であるカストレーション抵抗性Nkx3-1発現細胞 (CARNs) と呼ばれる新しい前立腺幹細胞群を特定しました.
科学分野:
- 泌尿器科 泌尿器科とは
- 幹細胞生物学 幹細胞生物学
- がん研究 がん研究
背景:
- 前立腺がんの起源は,正常な前立腺細胞から来ているのか,まだはっきりしていない.
- 幹細胞の個体群を理解することは,組織再生とがんの発症を理解する上で鍵となるものです.
研究 の 目的:
- 再生に関与する前立腺幹細胞を特定し,特徴づけること.
- 前立腺幹細胞の維持と機能におけるNkx3-1の役割を調査する.
- 特定された幹細胞が前立腺がんの発症の標的であるかどうかを判断する.
主な方法:
- ネズミにおける遺伝的系統マーク.
- 単細胞移植アッセイ 単細胞移植アッセイ
- 前立腺再生中の Nkx3-1 ミュータントマウスの分析.
- 特定された幹細胞におけるPten腫瘍抑制遺伝子の標的の削除.
主要な成果:
- Nkx3-1は,前立腺再生中に活発な幹細胞集団 (CARNs) をマークします.
- CARNsは,バイポテンシャルであり,自己再生し,前立腺組織を再構成することができます.
- Nkx3-1は前立腺幹細胞の機能を維持するために不可欠です.
- CARNsにおけるPtenの消去は,前立腺がんの急速な形成につながります.
結論:
- CARNsは,前立腺における新しいルミナル幹細胞集団を表しています.
- この幹細胞群は,前立腺の再生に不可欠です.
- CARNsは,腫瘍性変異の非常に効率的な標的であり,前立腺がんの発症を誘発する.
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