症状のない鹿は,便で感染性のプリオンを排泄する
Gültekin Tamgüney1, Michael W Miller, Lisa L Wolfe
1Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94143 USA.
Nature
|September 11, 2009
まとめ
症状のない鹿は,症状が現れる前に,便で感染性プリオンを排泄します. 慢性衰弱病 (CWD) のプリオンが長期間排泄され,糞便で放出されることは,鹿の集団に病気が広がるメカニズムを提供します.
科学分野:
- 獣医医学 獣医医学は,獣医医学というものです.
- 神経科学は神経科学である.
- 野生生物の生態学 野生生物の生態学
背景:
- スクレイピーや慢性衰弱症 (CWD) のような伝染性プリオン病は,動物集団内で自然に広がります.
- 症状のある動物の感染源は知られているが,流行におけるその役割は不明である.
研究 の 目的:
- 無症状の動物におけるプリオン流出を調査する.
- 慢性疲労性疾患 (CWD) の伝播における糞便の役割を決定する.
主な方法:
- ムール鹿 (Odocoileus hemionus) は,糞中のプリオン流出をモニターした.
- 症状のない鹿の排泄物サンプルを,サービッド・プリオンタンパク質 (PrP) を過剰に発現するトランス遺伝子マウスに注射した.
主要な成果:
- 感染性CWDプリオンは,無症状の鹿の15個の糞便サンプルのうち14個で検出されました.
- プリオンは,臨床症状の発症7〜11ヶ月前に放出されました.
- 糞便の総プリオン排出量は,病気の経過で脳のプリオン負荷に近似する可能性があります.
結論:
- で無症状のCWDプリオン流出は,病気の伝播の重要な要因です.
- 長期にわたる排泄は,鹿の群れにおけるCWDの流行の妥当なメカニズムを提供する.
- これは,鹿類の間の水平プリオン伝播の重要な経路を強調しています.
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