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A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
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遠隔作用増強剤のゲノム画像

Axel Visel1, Edward M Rubin, Len A Pennacchio

  • 1Genomics Division, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Nature
|September 11, 2009
PubMed
まとめ

人間の病気における非コーディングDNA変異の役割は十分に研究されていない. 最近の研究は,それらの重要性を強調しているが,そのメカニズムは,特に転写強化剤の場合は不明である.

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.