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Trihybrid Crosses02:27

Trihybrid Crosses

Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
Relative Velocity in Two Dimensions01:11

Relative Velocity in Two Dimensions

Relative velocity is the velocity of an object as observed from a particular reference frame, or the velocity of one reference frame with respect to another reference frame. The concept of relative velocity can be used to describe motion in two dimensions. Consider a particle P and two reference frames S and S′. The position of the origin of S′ as measured in S is , the position of P as measured in S′ is , and the position of P as measured in S is , which can be evaluated by utilizing vector...
Three-Dimensional Analysis of Strain01:29

Three-Dimensional Analysis of Strain

Three-dimensional strain analysis is crucial for understanding how materials deform under stress, particularly in elastic, homogeneous materials. This method employs principal stress axes to simplify complex stress states into more understandable forms. Subjected to stress, a small cubic element within a material either expands or contracts along these axes, transforming into a rectangular parallelepiped. This transformation effectively illustrates the material's deformation. The principal...
Two-Dimensional Microscopy in Microbiology01:29

Two-Dimensional Microscopy in Microbiology

Two-dimensional (2D) microscopy encompasses a range of optical techniques that capture images within a single focal plane, offering detailed representations of microscopic structures. These techniques are essential in biological and medical research, enabling the visualization of cellular and subcellular structures with different levels of contrast and specificity.There are several major types of 2D microscopy, each with strengths and applications.Bright-Field MicroscopyBright-field microscopy...
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
Differential Staining Technique01:26

Differential Staining Technique

Differential staining is an essential microbiological technique that exploits variations in cell wall structures to classify and identify microorganisms. It facilitates the distinction of bacteria, aiding in diagnostic and research applications. Two of the most widely used differential staining methods are Gram staining and acid-fast staining, both of which rely on the chemical and structural differences in bacterial cell walls.Gram Staining TechniqueGram staining differentiates bacteria by...

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Updated: May 25, 2026

Robust 3D DNA FISH Using Directly Labeled Probes
12:16

Robust 3D DNA FISH Using Directly Labeled Probes

Published on: August 15, 2013

染色体交差は3次元で描かれています.

Anita Göndör1, Rolf Ohlsson

  • 1Department of Microbiology, Tumor and Cell Biology, Nobels väg 16, Box 280, Karolinska Institute, SE-171 77 Stockholm, Sweden. anita.gondor@ki.se

Nature
|September 11, 2009
PubMed
まとめ

ゲノムは核内で物理的に相互作用し,ループやブリッジを形成します. これらのダイナミックな染色体相互作用は,遺伝子活動と核組織に影響を与え,発達と病気の洞察を提供します.

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • ゲノムは静的ではなく,ダイナミックな3次元 (3D) の核空間に存在する.
  • 染色体ループやブリッジのような物理的な相互作用は,ゲノム組織にとって極めて重要です.
  • これらの相互作用を理解することは,遺伝子調節と核建築の解読の鍵です.

研究 の 目的:

  • ゲノム内のダイナミックな物理的な相互作用の機能的影響を調査する.
  • 染色体相互作用が遺伝子の静止と活性化にどのように貢献するかを探求する.
  • ゲノム組織と可塑性の研究における技術的進歩の役割を強調する.

主な方法:

  • ゲノムの物理的な相互作用を検出および分析するために,高度な分子技術を活用します.
  • 3Dの核環境の中で分子レベルで染色体相互作用を調べる.
  • 観察された相互作用を遺伝子発現パターンと相関させる.

主要な成果:

  • 広範囲でダイナミックな物理的相互作用がゲノムの3D構造を形成することを実証した.
  • 染色体相互作用が遺伝子発現の調節に作用する証拠を提供した.

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Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging
07:28

Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging

Published on: March 23, 2020

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
11:25

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

Published on: January 25, 2020

関連する実験動画

Last Updated: May 25, 2026

Robust 3D DNA FISH Using Directly Labeled Probes
12:16

Robust 3D DNA FISH Using Directly Labeled Probes

Published on: August 15, 2013

Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging
07:28

Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging

Published on: March 23, 2020

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
11:25

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

Published on: January 25, 2020

  • 技術的進歩が,ゲノム機能のより深い理解をどのように可能にするかを示しました.
  • 結論:

    • ダイナミックなゲノム相互作用は,核構造と遺伝子調節の基本です.
    • これらの相互作用を検出する技術的進歩は,ゲノム可塑性についての理解を深めています.
    • これらの洞察は,開発,病気,環境への反応を理解するために重要である.