分子ネットワークは,一般的なヒト疾患のセンサーとドライバーとして機能します
1Pacific Biosciences, 1505 Adams Drive, Menlo Park, California 94025, USA. eschadt@pacificbiosciences.com
Nature
|September 11, 2009
まとめ
ゲノミクスの革命により,分子生物学と生理学を結びつけることができました. リバースエンジニアリング分子ネットワークは,DNAと環境要因を生理学的変化と結びつけることで,病気を理解するのに役立ちます.
科学分野:
- 分子生物学は分子生物学である.
- ゲノミクスゲノミクスとは
- システム生理学 システム生理学
- 臨床医学とは,臨床医学である.
背景:
- 分子生物学革命は,DNA,RNA,およびタンパク質の生物合成に焦点を当て,全システム生理学の理解にギャップをもたらしました.
- この分子の焦点は,基礎科学の発見と臨床医学の統合を妨げました.
研究 の 目的:
- 分子生物学と臨床医学のギャップを埋めるために.
- 分子ネットワークのリバースエンジニアリングのためのゲノミクスツールを活用する.
- 分子状態を病気の生理学的変異と結びつけるために.
主な方法:
- ゲノミクス革命のツールを活用して.
- 分子ネットワークのリバースエンジニアリング.
- ネットワークがDNAと環境の混乱をどのように感知するかを分析する.
主要な成果:
- 分子状態と生理学的結果とを結びつける枠組みを確立した.
- 分子ネットワークが乱れを感知する役割を示した.
- 病気に関連する生理学的変化を誘発する経路を特定した.
結論:
- ゲノミクスは,分子洞察を生理学的状態と結びつけるためのツールを提供します.
- 分子ネットワークのリバースエンジニアリングは,病気のメカニズムを理解する鍵です.
- このアプローチは,分子生物学を臨床アプリケーションに翻訳することを容易にする.
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