季節性情動障害と,光によるメラトニン抑制の季節性異常

C Thompson¹, D Stinson, A Smith

¹Department of Psychiatry, University of Southamptom, Royal South Hants Hospital, UK.

Lancet (London, England)

|September 22, 1990

まとめ

季節性感情障害 (SAD) の患者は,照明に対する感度が変化し,冬には感度が上昇し,夏には感度が低下する. 光への反応の季節的変動は,SADに関連しています.

科学分野:

クロノバイオロジークロノバイオロジー
神経内分泌学の神経内分泌学
精神科医は精神病を患っている.

背景:

季節性感情障害 (SAD) は,季節的なパターンを持つ気分障害です.
メラトニンの分泌は,光への曝露によって調節され,昼夜リズムに役割を果たします.
光感度の変化は,SADの病理生理学に寄与する可能性があります.

研究の目的:

SAD患者における光感受性の季節的変動を調査する.
季節ごとにSAD患者と健康な対照群の間で,光誘発によるメラトニン抑制を比較する.
冬と夏の間で,SAD患者の光の感受性が異なるかどうかを判断する.

主な方法:

12人のSAD患者と11人の健康な対照群は,冬と夏の間に光曝露試験 (2000ルックス対300ルックス) を受けました.
メラトニン分泌抑制は,光感受性の指標として測定されました.
光の強度間のメラトニン抑制の差異は季節的に分析されました.

主要な成果:

SADの患者は,対照群とは異なり,光に対する感受性の季節的変動が顕著であった.
冬には,SAD患者には,光に対する過敏性 (過敏性) が高まった.
夏には,SAD患者には,光に対する感受性の低下 (感受性の低下) が示されました.

結論:

SADは,光の感受性の変化の明確な季節的なパターンと関連しています.
これらの発見は,SADの季節的な再発の基礎となる潜在的な神経内分泌機構を示唆しています.
SADの治療的な光介入は,光の反応の季節的な違いを考慮する必要があるかもしれません.

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