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Updated: Jun 20, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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鉄を調節するユビキチンリガゼによる鉄の恒常性の制御

Ajay A Vashisht1, Kimberly B Zumbrennen, Xinhua Huang

  • 1Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Science (New York, N.Y.)
|September 19, 2009
PubMed
まとめ

ユーカリ細胞における鉄の調節には,鉄調節タンパク質2 (IRP2) の分解が含まれています. 研究者らは,SKP1-CUL1-FBXL5複合体を,IRP2タンパク質分解を担当するE3ユビキチンリガゼとして特定し,鉄のレベルとタンパク質の安定性を関連付けました.

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