関連する実験動画

Updated: Jun 20, 2026

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter
07:53

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter

Published on: April 17, 2026

PARP-1自動改変領域におけるADPリボシレーション部位の特定:分析と影響

Zhihua Tao1, Peng Gao, Hung-wen Liu

  • 1Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA.

Journal of the American Chemical Society
|September 22, 2009
PubMed
まとめ

研究者らは,Poly(ADP-ribose) ポリメラーゼ-1 (PARP-1) のドメインD内の3つの特定のADP-リボシレーション部位を特定しました. この研究では,自動改変がドメインDを超えて発生し,ドメインDはPARP-1の酵素活性に不可欠ではないことが明らかになりました.

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
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Protein Modifications in the RER

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RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Long-patch Base Excision Repair

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