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Updated: May 6, 2026

Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
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Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Published on: October 28, 2011

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神経細胞の微分化の謎を解明する

Bennett G Novitch1, Samantha J Butler

  • 1Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. bnovitch@ucla.edu

Cell
|September 22, 2009
PubMed
まとめ

GDE2 と Prdx1 を含む新しいチオール・レドックス反応は,神経原生細胞の細胞サイクルを調節することによって神経生成を促進します. この発見は,神経系の発達のメカニズムを明らかにしている.

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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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