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Updated: Apr 13, 2026

Presynaptically Silent Synapses Studied with Light Microscopy
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Published on: January 5, 2010

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シナプスPRG-1は,脂質リン酸媒介シグナル伝達の経由で興奮伝送を調節する

Thorsten Trimbuch1, Prateep Beed, Johannes Vogt

  • 1Institute of Cell Biology and Neurobiology and NeuroCure, Charité, Universitätsmedizin Berlin, Berlin, Germany.

Cell
|September 22, 2009
PubMed
まとめ

プラスティシティ関連遺伝子-1 (PRG-1) は,リソホスファティド酸 (LPA) 受容体と相互作用することによって,ヒポカンプスの興奮性を調節する. その欠如は発作を引き起こすが,PRG-1を回復したり,LPAシグナリングを遮断したりすることで,この過興奮を防ぐ.

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