子どもの脳マラリアの神経学的続変
D R Brewster1, D Kwiatkowski, N J White
1Royal Victoria Hospital, Banjul, The Gambia.
Lancet (London, England)
|October 27, 1990
まとめ
ガンビアの子どもたちの脳マラリアは,著しい死亡率と長期的な神経学的欠陥を引き起こしました. 生存者の半分以上は完全に回復したが,四分の一は主要な神経障害を経験し,病気を強調した.
科学分野:
- トロピカル・メディシン (熱帯医学)
- 小児神経学について
- 感染症 感染症は感染症です.
背景:
- ファルシパラムマラリアは,熱帯地域における小児疾患の主な原因である.
- 脳性マラリアは,重症な形態であり,子供にとって重大なリスクをもたらす.
- 神経学的続変は,重度のマラリア感染症に起因する可能性があります.
研究 の 目的:
- 子どものファルシパラムマラリアのアウトカムを調査し,脳マラリアに焦点を当てます.
- 脳のマラリアに関連する死亡率と神経学的欠陥を決定する.
- 罹患児の続発および長期的な回復に寄与する要因を特定する.
主な方法:
- ファルシパラムマラリアで入院したガンビアの604人の子供の遡及的分析.
- 脳のマラリア,重度の貧血,陰性血液フィルムの脳マラリアの疑いに基づく分類.
- 入院およびフォローアップ (1-6ヶ月) 時の死亡率,神経学的欠陥,および後遺症の評価.
主要な成果:
- 脳のマラリアの14%が死亡し,重度の貧血の7.8%が死亡しました.
- 脳性マラリアの生存者の12%は残留神経学的欠陥を持っていた.
- 一般的な後遺症には,半麻痺,皮質の失明,アファシア,アタキシアが含まれ,長時間の昏睡とが予備要因でした.
結論:
- 子どもの脳マラリアは,熱帯地域の神経障害の重要な原因です.
- 生き残った人のかなりの割合は,長期的な神経学的欠陥を経験します.
- 早期の認識と管理は,重篤なアウトカムと後遺症を軽減するために不可欠です.
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