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Updated: Jun 20, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

アミロイドベータの動態はオレキシンと睡眠覚醒サイクルによって調節されます

Jae-Eun Kang1, Miranda M Lim, Randall J Bateman

  • 1Department of Neurology, Washington University, St. Louis, MO 63110, USA.

Science (New York, N.Y.)
|September 26, 2009
PubMed
まとめ

目覚めと睡眠不足は,脳内のアミロイドベータ (Abeta) を増加させる. オレキシンのシグナル伝達がアベータレベルとプラーク形成に影響し,アルツハイマー病における睡眠-覚醒サイクルが役割を果たしていることを示唆しています.

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Electrocorticographic Recording of Cerebral Cortex Areas Manipulated Using an Adeno-Associated Virus Targeting Cofilin in Mice08:44

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