Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton08:50

The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

1.1K
In this work, an in vitro reconstitution approach is employed to study the poroelasticity of actomyosin gels under controlled conditions. The dynamics of the actomyosin gel and the embedded solvent are quantified, through which the network poroelasticity is demonstrated. We also discuss the experimental challenges, common pitfalls, and relevance to cell cytoskeleton...
1.1K
Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

3.5K
This protocol presents a method to perform rheology characterization of mucus that resides on gill rakers (GRs) of the silver carp. Viscoelastic characteristics of GR-mucus, obtained by measuring viscosity, storage and loss moduli, are evaluated for the apparent yield stress to understand the filter feeding mechanism in...
3.5K
The Diffusion of Passive Tracers in Laminar Shear Flow08:01

The Diffusion of Passive Tracers in Laminar Shear Flow

9.0K
A protocol for the study of the diffusion of passive tracers in laminar pressure-driven flow is presented. The procedure is applicable to various capillary pipe...
9.0K
Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

9.1K
Two different methods for characterizing the incipient particle motion of a single bead as a function of the sediment bed geometry from laminar to turbulent flow are...
9.1K
An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

9.0K
An experimentally accessible analog method for studying molecular hydrodynamic processes in dense fluids is presented. The technique uses particle image velocimetry of vibrated, high-restitution grain piles and allows direct, macroscopic observation of dynamical processes known and predicted to exist in strongly interacting, high density gases and...
9.0K
Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures10:56

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures

12.5K
Confocal microscopy is used to image quiescent and flowing colloid-polymer mixtures, which are studied as model systems for attractive suspensions. Image analysis algorithms are used to calculate structural and dynamic metrics for the colloidal particles that measure changes due to geometric...
12.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity.

Nature structural & molecular biology·2026
Same author

H3K27M-driven hypertranscription leads to a new targetable dependency in diffuse midline gliomas.

bioRxiv : the preprint server for biology·2026
Same author

RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress.

Nature cell biology·2026
Same author

Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes.

Stem cell reports·2025
Same author

Cryo-electron microscopic visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2.

Science (New York, N.Y.)·2025
Same author

EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers.

Nature communications·2025
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 12, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

3.5K

コンデンシン (((g) クロスオーバーコントロールを数回のブレイクに

Simon J Boulton1

  • 1DNA Damage Response laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, UK. simon.boulton@cancer.org.uk

Cell
|October 7, 2009
PubMed
まとめ
この要約は機械生成です。

分離期間の適切な染色体分離にはクロスオーバーが必要です. コンデンシン複合体は染色体構造を確立し,メッツとメイヤー (2009) によると,メオティック二重鎖の断絶を制御することによって,クロスオーバーの頻度と分布を調節する.

さらに関連する動画

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

Published on: February 22, 2018

9.1K
An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

Published on: December 4, 2017

9.0K

関連する実験動画

Last Updated: Jan 12, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

3.5K
Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

Published on: February 22, 2018

9.1K
An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

Published on: December 4, 2017

9.0K

科学分野:

  • 細胞生物学 細胞生物学
  • 遺伝学 遺伝学とは
  • 分子生物学は分子生物学である.

背景:

  • ミエオシスには,最初のミエオシス分裂の間に正確な分離のために,染色体ペアごとに少なくとも1つのクロスオーバーが必要です.
  • クロスオーバー分布と頻度を制御するメカニズムは,繁殖の成功に不可欠です.

研究 の 目的:

  • 媒介性再結合の調節におけるコンデンシン複合体の役割を調査する.
  • 高階染色体構造がクロスオーバー形成にどのように影響するかを決定する.
  • 分離分裂におけるコンデンシン,染色体構造,および二重鎖断裂分布の関係を解明する.

主な方法:

  • モデル生物におけるメオティック再結合を研究するために,遺伝学や分子生物学技術を活用した.
  • 染色体構造の確立における特定のコンデンシン複合体の機能を調査した.
  • コンデンシン活動に関連したメオティック二重鎖断裂の分布と頻度を分析した.

主要な成果:

  • コンデンシン複合体は,微分化の過程で高次元の染色体構造を確立するために重要であることが実証されました.
  • コンデンシン媒介の染色体構造がクロスオーバー再結合を直接制御する証拠を提供した.
  • コンデンシンがメオティック二重鎖断裂の分布と頻度を制御し,それによってクロスオーバー結果に影響することを示した.

結論:

  • コンデンシン複合体は,染色体構造の制御を通じて,中性交叉再結合を調節する上で重要な役割を果たします.
  • コンデンシンによる上位階の染色体構造の確立は,適切なクロスオーバーパターニングと,その後の染色体分離を確実にするための重要なメカニズムです.
  • これらの発見は,メオティック・フィデリティを制御する基本的なプロセスに関する新しい洞察を提供します.