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エストロゲンは神経経路と性特異的行動を男性化します
Melody V Wu1, Devanand S Manoli, Eleanor J Fraser
1Program in Neuroscience, University of California-San Francisco, San Francisco, CA 94158, USA.
Cell
|October 7, 2009
まとめ
テストステロン テストステロン
科学分野:
- 神経内分泌学の神経内分泌学
- 行動神経科学は,行動神経科学である.
- 発達神経科学とは
背景:
- テストステロンとエストロゲンを含む性ホルモンは,脳の発達と性特有の行動に不可欠です.
- 男性の行動におけるテストステロンとエストロゲンの経路の相互作用は完全に理解されていません.
- テストステロンはアンドロゲン受容体 (AR) を介して作用し,脳内のアロマターゼによってエストロゲンに変換されます.
研究 の 目的:
- 男性の行動を制御する神経回路の性的差別化と活性化におけるアロマターゼの役割を調査する.
- 脳におけるテストステロンとエストロゲンのシグナル伝達の交差点を明らかにするために.
- アロマターゼ独立系とアロマターゼ依存系経路が男性化に与える貢献を決定する.
主な方法:
- アロマターゼ発現ニューロンにおける性二形態の検査.
- 女性におけるアロマターゼ発現ニューロンに対するテストステロンとエストロゲンの影響を調査した.
- 評価された男性特有の行動 (攻撃性,尿のマーキング) は,AR変異性男性と新生児のエストロゲンにさらされた女性で評価された.
- 利用された遺伝子モデル (AR変異体) とホルモン操作.
主要な成果:
- アロマターゼ発現ニューロンの数とプロジェクションにおいて,有意な性二型性を示した.
- これらのニューロンの男性化がアンドロゲン受容体 (AR) から独立していることが示されました.
- テストステロンやエストロゲンが女性におけるこれらのニューロンの男性化を引き起こすことがわかった.
- アロマターゼは,ARシグナルがない場合でも,男性の攻撃性と尿のマーキングを活性化するために重要であるという証拠を提供した.
結論:
- テストステロンのエストロゲンへの芳香化は,男性の領土行動の基礎となる神経回路の発達と活性化において重要な役割を果たします.
- アロマターゼによって媒介されるエストロゲンシグナル伝達は,特定のニューロン集団の性差別化に不可欠である.
- アロマターゼ発現ニューロンの男性化にはアンドロゲン受容体 (AR) が必要とされず,ホルモンの影響のための代替経路を強調しています.
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