GABAergic 前シナプス抑制回路の構築における厳格な特異性
J Nicholas Betley1, Christopher V E Wright, Yoshiya Kawaguchi
1Howard Hughes Medical Institute, Kavli Institute of Brain Science, Departments of Neuroscience, Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Cell
|October 7, 2009
まとめ
感覚標的はGABAergicインターニューロンを誘導し,脊髄で阻害回路を形成する. 脳由来神経栄養因子 (BDNF) は,これらの重要なニューロンのシナプス発育と機能に不可欠です.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学について
- 分子生物学は分子生物学である.
背景:
- GABAergicインターニューロンは,ニューラルコーディングと阻害回路組立に不可欠です.
- 脊髄のGABAergicインターニューロンは,前・後シナプス阻害を通じて,感覚から運動ニューロン信号伝達を調節する.
研究 の 目的:
- 前シナプス阻害を媒介するGABAergicインターニューロンの接続性とシナプス分化を制御するメカニズムを解明する.
- これらの阻害回路の組織を指揮する感覚標的の役割を調査する.
主な方法:
- 感覚端末の不在でGABAergicニューロンの行動を調査しました.
- 感覚特有の脳由来神経栄養因子 (BDNF) がシナプス分化に及ぼす影響を調べました.
- 重要なGABA合成酵素であるGAD65の発現を分析した.
主要な成果:
- GABAergicインターニューロンは,他の標的と接続できず,感覚端末が欠けるとプレシナプス分化を経験します.
- これらの内部ニューロンの軸索は,感覚の入力なしに,腹側脊髄から引き戻します.
- 感覚特異的なBDNFは,これらの内部ニューロンの特徴であるGAD65のシナプス発現を誘導します.
結論:
- GABAergicインターニューロンの接続性とシナプス成熟は,それらの特定の感覚標的によって導かれます.
- BDNFを含む感覚認識とシグナリングの正確なプログラムは,前シナプス抑制を媒介する哺乳類の中枢神経系のGABAergic回路の組織を制御します.
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