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Updated: Jun 19, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

E7389 C14-C35とハリコンドリンのC14-C38構成要素の新合成:還元サイクルとオキシ-マイケルサイクルアプローチ

Cheng-Guo Dong1, James A Henderson, Yosuke Kaburagi

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|October 8, 2009
PubMed
まとめ

この研究では,2つの新しいアプローチを使用して,費用対効果の高いクロム媒介結合反応を提示しています. これらの方法は,スケーリングに適した複雑な構成要素を合成する際に高い効率とステレオ選択性を達成します.

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Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...
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