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Updated: Jun 19, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

アザベタ3-サイクロペプチド:窒素のキラリティを制御する新しい方法

Clémence Mocquet1, Arnaud Salaün, Paul Claudon

  • 1ICMV and CSM, UMR CNRS 6226, Université de Rennes I, 35042 Rennes Cedex, France.

Journal of the American Chemical Society
|October 8, 2009
PubMed
まとめ

研究者は,ヒドラジノまたはアミノ酸を使用して新しいマクロサイクルを合成しました. これらの安定した構造は,ダイナミックなエナンチオセレクションを示し,より大きな分子におけるキラリティを初めて制御します.

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Structure of Amines01:19

Structure of Amines

The hybridized nitrogen atom in amines possesses a lone pair of electrons and is bound to three substituents with a bond angle of around 108°, which is less than the tetrahedral angle of 109.5°. However, the C–N–H bond angle is slightly larger at 112°, with a carbon–nitrogen bond length of 147 pm. This carbon–nitrogen bond length of of amines is longer than the carbon–oxygen bond of alcohols (143 pm) but shorter than alkanes’ carbon–carbon bond (154 pm). These aspects are illustrated in Figure...
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¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

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