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Updated: Jun 19, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

形態アセタル改変オリゴヌクレオチドにおける構造,水分化,熱安定性の相互作用:RNAはDNAよりも nonionic 改変を好ましく容認する可能性がある

Andrej Kolarovic1, Emma Schweizer, Emily Greene

  • 1Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.

Journal of the American Chemical Society
|October 15, 2009
PubMed
まとめ

フォーマセタル改変はRNAヘリクスを安定させますが,DNAヘリクスを不安定化しますので,RNAはDNAよりも脊椎の変化をよく容認することが示唆されます. この発見は,RNAベースの遺伝子制御戦略にとって極めて重要です.

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