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Updated: Jun 19, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

アミロイドゲンベータ(2) - マイクログローブリンのK3断片がイオンチャネルを形成する:透析関連のアミロイドーシスへの影響

Mirela Mustata1, Ricardo Capone, Hyunbum Jang

  • 1Center for Nanomedicine and Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA.

Journal of the American Chemical Society
|October 15, 2009
PubMed
まとめ

ベータ (((2) - マイクログローブリンアミロイド堆積は,透析に関連するアミロイド症を引き起こす. K3の断片はイオンチャネルを形成し,腎臓の細胞にカルシウム吸収をもたらし,この断片が病気を媒介することを示唆しています. これは,毒性におけるアミロイドモチーフの潜在的な汎用的な役割を強調しています.

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Use of Two Dimensional Semi-denaturing Detergent Agarose Gel Electrophoresis to Confirm Size Heterogeneity of Amyloid or Amyloid-like Fibers10:10

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