心血管疾患と股関節骨折のリスク
Ulf Sennerby1, Håkan Melhus, Rolf Gedeborg
1Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, SE-751 85 Uppsala, Sweden.
JAMA
|October 22, 2009
まとめ
心血管疾患 (CVD) は,股関節骨折のリスクを大幅に増加させます. ライフスタイルだけでなく,共有された遺伝的要因が,CVDと骨粗鬆症の骨折の間の関連に寄与しています.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- エピデミオロジー エピデミオロジー
- 遺伝学 遺伝学とは
背景:
- 新興の証拠は,心血管疾患 (CVD) と骨粗鬆性骨折を関連付けています.
- これらの一般的な状態には,共通の基礎的病因が疑われる.
研究 の 目的:
- CVDとその後の股関節骨折リスクとの関連を調査する.
- 双子の研究デザインを使用して,この関係における遺伝的およびライフスタイル要因の役割を決定します.
主な方法:
- スウェーデンの双子 (31,936人,1914年~1944年生まれ) を50歳から追跡した.
- 心血管疾患 (CVD) と股関節骨折のデータは,国家登録 (1964-2005) から収集されました.
- コックス比率ハザード回帰モデルは,時間依存の被曝を分析した.
主要な成果:
- CVDの診断は,実質的に増加した骨折率 (例えば,心不全HR=4.40,脳卒中HR=5.09) と関連していました.
- CVDの診断を受けていない双生児でさえ,股関節骨折のリスクが高く,共通の遺伝的影響を示唆しています.
- 偽曝露した双子の股関節骨折のリスク比率は,心不全では3.74,脳卒中では2.29でした.
結論:
- 心血管疾患は,その後の股関節骨折の重要な危険因子です.
- 同胞で観察されたリスクの増加は,CVDと骨粗鬆症の骨折関連が遺伝的要素に基づいていることを示唆しています.
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