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Updated: Jun 19, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

プラテンシミシンと関連する自然産物の総合合成

K C Nicolaou1, Ang Li, David J Edmonds

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. kcn@scripps.edu

Journal of the American Chemical Society
|October 31, 2009
PubMed
まとめ

研究者はプラテンシミシンと関連する化合物を合成し,薬剤耐性細菌に対して有効な新しい抗生物質を開発しました. この研究では,抗生物質の核構造を構成するための収束戦略と2つの非対称な経路の詳細が示されています.

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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

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