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関連する概念動画

Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

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関連する実験動画

Updated: Jun 19, 2026

An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

組合せ結合は,時空間のシス調節活動を予測する.

Robert P Zinzen1, Charles Girardot, Julien Gagneur

  • 1European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.

Nature
|November 6, 2009
PubMed
まとめ
この要約は機械生成です。

科学者たちは,転写因子結合データを用いて遺伝子発現パターンを予測する新しい方法を開発した. このアプローチは,ファクター関数の事前の知識なしに,開発中に規制の景観を正確に解読します.

さらに関連する動画

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

関連する実験動画

Last Updated: Jun 19, 2026

An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

科学分野:

  • 発達生物学 発達生物学について
  • ゲノミクスゲノミクスとは
  • コンピュータ生物学 コンピュータ生物学

背景:

  • 精密な遺伝子発現パターンは,シス調節モジュールに結合する転写因子によって制御される,発達にとって極めて重要です.
  • ゲノム全体の転写因子占有データがありますが,規制の状況を解読することは依然として困難です.

研究 の 目的:

  • 空間時間的なシス規制活動の予測のための新しいデータベースのアプローチを開発する.
  • ドロソフィラ・メソデルマの発達中のシス調節モジュールの高解像度アトラスを作成する.

主な方法:

  • in vivoの転写因子結合および強化剤の活性データを使用した.
  • トレーニングされたサポートベクトルマシンは,表現パターンを予測するために,既知のシス調節モジュールの結合プロファイルを使用します.
  • 予測を検証するために,in vivoのトランスジェニックレポーターアッセイが採用されています.

主要な成果:

  • cis規制モジュールとその時間占有量の詳細なアトラスを生成しました.
  • 5つの時空表現パターンを高精度で予測しました.
  • 転写因子結合において予想外の可塑性が観察され,同様の発現結果につながった.

結論:

  • この新しいアプローチは,転写因子結合データからシス調節活性を正確に予測します.
  • この方法は,転写因子配列の親和性,機能,または発現に関する事前の知識を必要としないため,広く適用できます.
  • 開発中の転写因子結合における可塑性を明らかにした.