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Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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HMGBタンパク質は,核酸媒介の先天性免疫反応の普遍的な看守として機能する

Hideyuki Yanai1, Tatsuma Ban, ZhiChao Wang

  • 1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Nature
|November 6, 2009
PubMed
まとめ

高流動性グループボックス (HMGB) タンパク質は,すべての免疫原性核酸を結合する普遍的なセンチネルとして作用します. 欠乏すると,先天的な免疫反応が低下し,免疫に不可欠な核酸感知の階層が明らかになる.

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