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Updated: Jun 18, 2026

[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
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[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

アミノフェノールのO-およびN-アリレーションのためのオートホーナルCu-およびPdベースの触媒システム

Debabrata Maiti1, Stephen L Buchwald

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Journal of the American Chemical Society
|November 11, 2009
PubMed
まとめ

アミノフェノールの選択的O-およびN-アリレーションのための新しい銅とパラジウム触媒システムを開発しました. これらの方法は,アリルハリドを使用した潜在的に治療的な化合物の効率的な合成を可能にします.

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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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