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Updated: Jun 18, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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高度還元性イテラティブポリケチド合成酵素の完全な復元

Suzanne M Ma1, Jesse W-H Li, Jin W Choi

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.

Science (New York, N.Y.)
|November 11, 2009
PubMed
まとめ

研究者は,酵母でロバスタチンノンアケチド合成酵素 (LovB) を発現させ,その機能を再構成した. この酵素はコレステロールを下げるロバスタチンを生成し,そのパートナー酵素であるLovCはゲートキーパーとして作用する.

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