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Updated: Jun 18, 2026

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
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バクテリアのフォスフォパントオセノイルシステイン合成酵素の選択的阻害剤

James D Patrone1, Jiangwei Yao, Nicole E Scott

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

Journal of the American Chemical Society
|November 12, 2009
PubMed
まとめ

研究者らは,細菌のフォスフォパントテノリシステイン合成酵素 (PPCS) を阻害する重要な中間物質の新しい模倣を設計した. これらの化合物は,バクテリアのPPCSに対する高い選択性を示し,新しい抗菌療法のための可能性を秘めています.

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