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Updated: Jun 18, 2026

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation
09:40

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation

Published on: June 27, 2017

核CDKは,BMPとTGF-β経路におけるSmad転写の活性化とターンオーバーを駆動する

Claudio Alarcón1, Alexia-Ileana Zaromytidou, Qiaoran Xi

  • 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Cell
|November 17, 2009
PubMed
まとめ

新しい研究は,サイクリン依存キナーゼCDK8/9がSmadタンパク質をリン酸化し,その活動とターンオーバーを促進することを明らかにしています. この二重な役割は,成長因子β (TGF-β) と骨形態遺伝タンパク質 (BMP) 信号伝達経路の変換に極めて重要です.

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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

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