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Updated: Jun 18, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

ポリケチド生物合成における立体化学的制御の生化学的基礎

Chiara R Valenzano1, Rachel J Lawson, Alice Y Chen

  • 1Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912-9108, USA.

Journal of the American Chemical Society
|November 26, 2009
PubMed
まとめ

ポリケチド合成酵素は,ケトリデクタゼドメインを介してステレオ化学を制御する. メチルグループのエピメリゼーションは,鎖の延長後に発生し,ケトレデクタゼドメイン自体によって触媒されます.

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