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Updated: May 6, 2026

Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale

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迅速なE2-E3の組立と分解により,クリン-RINGのユビキチンリガース基板のプロセシブユビキティレーションが可能になります

Gary Kleiger1, Anjanabha Saha, Steven Lewis

  • 1Howard Hughes Medical Institute and the Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

Cell
|December 1, 2009
PubMed
まとめ

ユビキチン-プロテアソーム系は,分解のためにポリユビキチン鎖を必要とします. 研究者らは,Cdc34とSCFリガゼの間の静電相互作用が,ダイナミックでプロセス性鎖合成を可能にし,関連する酵素にわたって保存される可能性が高いメカニズムであることを発見しました.

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