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Updated: Jun 18, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

ペプチド核酸のループと骨幹の改変は,g-四重複結合選択性を改善する.

Sabrina Lusvarghi1, Connor T Murphy, Subhadeep Roy

  • 1Departments of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.

Journal of the American Chemical Society
|December 2, 2009
PubMed
まとめ

研究者らは,グアニンに富んだペプチド核酸 (PNA) オリゴーマーを改変して,G-クアドルプレックス形成の選択性をデュプレックスよりも高めました. 脊椎の改変により,標的DNAとRNAへのPNA結合が改善され,遺伝子調節と抗がん剤の開発が進められました.

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