運動は,循環する白血球と血管壁の細胞老化を防ぐ

Christian Werner¹, Tobias Fürster, Thomas Widmann

¹Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.

Circulation

|December 2, 2009

まとめ

運動は,テロメア安定化タンパク質の調節を向上させ,マウスとヒトのアポトーシスを減らし,血管の健康を改善します. これは,内皮のストレス抵抗性を促進し,老化を遅らせる可能性があります.

科学分野:

心血管生物学心血管生物学
分子生物学は分子生物学である.
ゲロントロジーはゲロントロジーの学科です.

背景:

運動が血管に与える効果の分子基盤は不明である.
テロメア縮小は,老化と細胞衰老に関連しています.
テロメア生物学に対する運動の影響を理解することは,老化に関する研究にとって極めて重要です.

研究の目的:

運動がマウスの血管テロメア生物学と内皮アポトーシスにどのように影響するかを調査する.
人間のアスリートにおけるテロメア生物学に対する耐久力トレーニングの影響を調査する.
運動誘発性血管保護の背後にある分子メカニズムを解明する.

主な方法:

ネズミは3週間,自発的に走行させられ,大動脈と血液の主要な分子マーカーを分析した.
トランスジェニックマウスモデルでは,eNOSとTERTの相乗効果を調査した.
人間のアスリートの白血球テロメア生物学は,訓練されていない個人と比較されました.

主要な成果:

運動は,ネズミの血管系と血液でテロメラーゼ活性とテロメラー結合タンパク質 (TRF2,Ku70) を増加させた.
運動は,アポトーシス調節剤 (CHK2,p16,p53) を減少させ,誘発アポトーシスから保護します.
耐久性アスリートではテロメラーゼ活性が高く,テロメアが安定し,細胞サイクル阻害剤が少なくなりました.

結論:

身体活動は,マウスとヒトの両方のテロメア安定化タンパク質を調節する.
運動は,ストレスに起因する血管アポトーシスから保護します.
運動は,血管の健康を維持し,潜在的に老化プロセスを緩和するのに重要な役割を果たします.

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