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Updated: Jun 18, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

ヒトの小島型アミロイドポリペプチドモノマーは,オーダーされたベータヘアピンを形成する:可能性のある直接のアミロイド原性前駆体

Nicholas F Dupuis1, Chun Wu, Joan-Emma Shea

  • 1Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, USA.

Journal of the American Chemical Society
|December 3, 2009
PubMed
まとめ

ヒューマン・アイレット・アミロイド・ポリペプチド (IAPP) モノマーはベータ-ヘアピン構造を採用し,イオン移動質量スペクトロメトリと分子動態シミュレーションで特定されています. これらの構造は,II型糖尿病におけるIAPPフィブリレーションに不可欠です.

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