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HIF2alpha PAS-Bにおける完全に埋もれた穴内のリガンド結合の原理

Jason Key1, Thomas H Scheuermann, Peter C Anderson

  • 1Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA.

Journal of the American Chemical Society
|December 3, 2009
PubMed
まとめ

小さな分子は,閉じた構造にもかかわらず,HIF2alpha PAS-Bドメインに素早く結合します. この結合は乱雑な移行状態を含み,リガンドの侵入を促進するダイナミックなタンパク質を示唆する.

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