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Updated: Jun 18, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
10:31

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

プロリンイソメラーゼの隠された代替構造は,触媒作用に不可欠です

James S Fraser1, Michael W Clarkson, Sheena C Degnan

  • 1Department of Molecular and Cell Biology/QB3, University of California, Berkeley, California 94720-3220, USA.

Nature
|December 4, 2009
PubMed
まとめ

酵素触媒の理解には,タンパク質のダイナミクスに関する原子レベルの洞察が必要です. この研究は,ヒトサイクロフィリンA (PPIA) の集団運動が,機能的な小型の形状を安定させることで,その触媒力に直接貢献する方法を明らかにしています.

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X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep105011:27

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