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Updated: Jun 18, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
07:10

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

HIV-1 gp120のCD4結合部位における免疫逃避の構造的基礎

Lei Chen1, Young Do Kwon, Tongqing Zhou

  • 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|December 8, 2009
PubMed
まとめ

HIV-1のCD4結合部位 (CD4BS) を標的とするほとんどの抗体は,ウイルスを中和することができません. 構造分析は,微妙な認識差異が,弱中和抗体がHIV-1 gp120をウイルススパイクと相容れない形状で結合させ,耐性を授与することを示しています.

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