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豆食品の摂取量と乳がんの生存率
Xiao Ou Shu1, Ying Zheng, Hui Cai
1Department of Medicine, Vanderbilt Epidemiology Center, 2525 West End Ave, Ste 600, Nashville, TN 37203-1738, USA. xiao-ou.shu@vanderbilt.edu
JAMA
|December 10, 2009
まとめ
乳がんの診断後の大豆食品の消費は,より低い死亡率と再発率に関連しています. この発見は,様々な乳がんタイプとタモキシフェンの使用に適用され,生存者のための潜在的な食事の利点を提供しています.
科学分野:
- 腫瘍学 腫瘍学
- 栄養科学とは,栄養科学である.
- エピデミオロジー エピデミオロジー
背景:
- ソーヤフードには,乳がんのリスク軽減特性を有する強力なフィトエストロゲンであるイソフラボンが含まれています.
- 大豆のエストロゲン作用と,タモキシフェンなどの乳がん治療薬との相互作用に関する懸念があります.
研究 の 目的:
- 乳がんの生存者における診断後の大豆食品摂取量と死亡率の関連性を調査する.
- 乳がん再発率に対する大豆食品消費の影響を評価する.
主な方法:
- 5042人の中国の女性乳がん生存者のコホート研究 (上海乳がん生存研究).
- 診断後の食事,ライフスタイル,および臨床的要因に関するデータを収集し,重要な統計のリンクを通じてフォローアップします.
- コックス回帰分析は,関連性を評価するために使用され,混同因子を調整し,時間依存の変数として大豆の摂取を扱う.
主要な成果:
- 大豆食品 (大豆タンパク質またはイソフラボン) の摂取量が高いことは,全死亡率とがん再発率と逆に関連していました.
- 大豆タンパク質摂取の最高四分位は,最も低い四分位と比較して29%低い死亡リスクと32%低い再発リスクを示しました.
- これらの保護的関連は,エストロゲン受容体陽性および陰性乳がんおよびタモキシフェン使用者および非使用者の両方で観察されました.
結論:
- 大豆食品の消費は,乳がん患者の死亡率と再発リスクの低下と有意に関連しています.
- ダイエット用大豆は,更年期状態や特定の治療法に関係なく,乳がんの生存者にとって有益である可能性があります.
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