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Updated: Jun 17, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
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NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins

Published on: November 1, 2024

固体核磁気共鳴による急速なタンパク質折り畳みプロセスにおける一時的な中間物質の検出

Kan-Nian Hu1, Wai-Ming Yau, Robert Tycko

  • 1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA.

Journal of the American Chemical Society
|December 17, 2009
PubMed
まとめ

固体NMRでは,タンパク質HP35が冷凍解凍時にマイクロ秒以内に二次構造を素早く形成することを示しています. しかし,完全な三次構造形成,または折り畳みは,より遅い時間スケールで発生し,以前の推定が不正確である可能性があることを示唆しています.

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