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Updated: Jun 17, 2026

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

設計された二次性エピディチオジケトピペラジンによる低酸素誘導性転写因子複合体の直接的抑制

Katherine M Block1, Hui Wang, Lajos Z Szabó

  • 1Department of Chemistry and Biochemistry, The University of Arizona, 1306 East University Boulevard, Tucson, Arizona 85721, USA.

Journal of the American Chemical Society
|December 17, 2009
PubMed
まとめ

研究者らは,低酸素による遺伝子発現を阻害する小さな分子を設計し,腫瘍の成長を潜在的に抑制しました. この標的型アプローチは,重要なタンパク質の相互作用を妨害し,がんの進行に対する新しい戦略を提供します.

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